Article
Cluster headache is associated with the G1246A polymorphism in the hypocretin receptor 2 gene.
Neurology - 27 Jun 2006
Schürks M, Kurth T, Geissler I, Tessmann G, Diener H-C, Rosskopf D
Abstract excerpt
The G1246A polymorphism in the gene of the hypocretin receptor 2 (HCRTR2) has been linked to the risk for cluster headache (CH). The authors examined this association in a large sample of 226 patients with CH and 266 controls from Germany. The genotype and allele distribution varied significantly between patients and controls. Homozygous carriers of the G-allele had a twofold increase in risk for CH (OR 1.97; 95%...
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