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Article

Wnt/β-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency

19 Mar 2007

Abstract excerpt

Embryonic stem cells (ESCs) represent an important research tool and a potential resource for regenerative medicine. Generally, ESCs are cocultured with a supportive feeder cell layer of murine embryonic fibroblasts, which maintain the ESCs' capacity for self-renewal and block spontaneous differentiation. These cumbersome conditions, as well as the risk of xenobiotic contamination of human ESCs grown on murine...

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PMID: 17372190
DOI: 10.1073/pnas.0701331104

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