Article
Recombination favors the evolution of drug resistance in HIV-1 during antiretroviral therapy.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jul 2007
Carvajal-Rodríguez Antonio, Crandall Keith A, Posada David
Abstract excerpt
We studied the relationship between recombination and the fixation time of multiple drug resistance mutations after HIV-1 drug therapy, under a set of different realistic scenarios. We have generalized a previous model by Bretscher et al. [Bretscher, Althaus, Muller, Bonhoeffer, 2004. Recombination in HIV and the evolution of drug resistance: for better or for worse? Bioessays 26(2), 180-188] in order to explore...
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