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Article

(A)symmetric stem cell replication and cancer.

PLoS computational biology - 16 Mar 2007

Dingli David, Traulsen Arne, Michor Franziska, Michor Fransizka

Abstract excerpt

Most tissues in metazoans undergo continuous turnover due to cell death or epithelial shedding. Since cellular replication is associated with an inherent risk of mutagenesis, tissues are maintained by a small group of stem cells (SCs) that replicate slowly to maintain their own population and that give rise to differentiated cells. There is increasing evidence that many tumors are also maintained by a small...

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Identifiers

PMID: 17367205
DOI: 10.1371/journal.pcbi.0030053
PMCID: PMC1828703

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