Article
Association of CYP1B1 germ line mutations with hepatocyte nuclear factor 1alpha-mutated hepatocellular adenoma.
Cancer research - 15 Mar 2007
Jeannot Emmanuelle, Poussin Karine, Chiche Laurence, Bacq Yannick, Sturm Nathalie, Scoazec Jean-Yves, Buffet Catherine, Van Nhieu Jeanne Tran, Bellanné-Chantelot Christine, de Toma Claudia, Laurent-Puig Pierre, Bioulac-Sage Paulette, Zucman-Rossi Jessica
Abstract excerpt
Biallelic somatic mutations of TCF1 coding for hepatocyte nuclear factor 1alpha (HNF1alpha) are found in 50% of the hepatocellular adenoma (HCA) cases usually associated with oral contraception. In rare cases, HNF1alpha germ line mutations could also predispose to familial adenomatosis. In order to identify new genetic factors predisposing to HNF1alpha-mutated HCA, we searched for mutations in genes involved in...
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