Article
Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel.
Molecular cancer therapeutics - 1 Mar 2007
Sarkaria Jann N, Yang Lin, Grogan Patrick T, Kitange Gaspar J, Carlson Brett L, Schroeder Mark A, Galanis Evanthia, Giannini Caterina, Wu Wenting, Dinca Eduard B, James C David
Abstract excerpt
In the current study, we examined a panel of serially passaged glioblastoma xenografts, in the context of an intracranial tumor therapy response model, to identify associations between glioblastoma molecular characteristics and tumor sensitivity to the epidermal growth factor receptor (EGFR) kinase inhibitor erlotinib. From an initial evaluation of 11 distinct glioblastoma xenografts, two erlotinib-sensitive...
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