Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development.

doi:10.1016/j.ccell.2018.06.006

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Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development.

Cancer cell - 9 Jul 2018

Binder Zev A, Thorne Amy Haseley, Bakas Spyridon, Wileyto E Paul, Bilello Michel, Akbari Hamed, Rathore Saima, Ha Sung Min, Zhang Logan, Ferguson Cole J, Dahiya Sonika, Bi Wenya Linda, Reardon David A, Idbaih Ahmed, Felsberg Joerg, Hentschel Bettina, Weller Michael, Bagley Stephen J, Morrissette Jennifer J D, Nasrallah MacLean P, Ma Jianhui, Zanca Ciro, Scott Andrew M, Orellana Laura, Davatzikos Christos, Furnari Frank B, O'Rourke Donald M

Abstract excerpt

We explored the clinical and pathological impact of epidermal growth factor receptor (EGFR) extracellular domain missense mutations. Retrospective assessment of 260 de novo glioblastoma patients revealed a significant reduction in overall survival of patients having tumors with EGFR mutations at alanine 289 (EGFRA289D/T/V). Quantitative multi-parametric magnetic resonance imaging analyses indicated increased...

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PMID: 29990498
DOI: 10.1016/j.ccell.2018.06.006
PMCID: PMC6424337

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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