Article
Molecular mechanisms underlying effects of epidermal growth factor receptor inhibition on invasion, proliferation, and angiogenesis in experimental glioma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2009
Guillamo Jean-Sébastien, de Boüard Sophie, Valable Samuel, Marteau Lena, Leuraud Pascal, Marie Yannick, Poupon Marie-France, Parienti Jean-Jacques, Raymond Eric, Peschanski Marc
Abstract excerpt
PURPOSE: Epidermal growth factor receptor (EGFR) signal transduction pathways are implicated in malignant glioma aggressiveness and promote tumor cell invasion, proliferation, and angiogenesis. Nevertheless, response to EGFR tyrosine kinase inhibitor gefitinib (Iressa, ZD1839) has been disappointing in clinical trials. One potential explanation may come from the diversity of molecular alterations seen in gliomas....
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