Article
Methylenetetrahydrofolate reductase C677T mutation and nonalcoholic fatty liver disease.
Digestive diseases and sciences - 1 May 2007
Serin Ender, Güçlü Mustafa, Ataç F Belgin, Verdi Hasibe, Kayaselçuk Fazilet, Ozer Birol, Bilezikçi Banu, Yilmaz Uğur
Abstract excerpt
A mutation in the methylenetetrahydrofolate reductase (MTHFR) gene is known as one of the causes of hyperhomocyteinemia. The oxidation products of homocysteine can initiate lipid peroxidation, which has a central role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). We aimed to assess the possible role of the MTHFR C677T mutation in the progression of simple steatosis to an advanced form of NAFLD....
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