Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cutaneous β-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling

30 Apr 2012

Abstract excerpt

The Notch signaling pathway is a key determinant in keratinocyte differentiation and growth cycle arrest, and has been reported to have a tumor suppressor function in skin. The papillomavirus life cycle is intricately linked to the differentiation status of keratinocytes. Papillomaviruses are associated with benign proliferative epithelial lesions in their respective hosts. Although human papillomaviruses (HPVs)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer and Skin Lesions
Share to Cancer-related Molecular Pathways
Share to Cervical Cancer and HPV Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22547818
DOI: 10.1073/pnas.1205991109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cutaneous β-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signalingPMID 22547818Read ↗

The Human Papillomavirus Type 8 E6 Protein Interferes with NOTCH Activation during Keratinocyte DifferentiationSemantic proximity Read ↗

The HPV8 E6 protein targets the Hippo and Wnt signaling pathways as part of its arsenal to restrain keratinocyte differentiationSemantic proximity Read ↗

Association of papillomavirus E6 proteins with either MAML1 or E6AP clusters E6 proteins by structure, function, and evolutionary relatednessSemantic proximity Read ↗

Cutaneous HPV8 and MmuPV1 E6 Proteins Target the NOTCH and TGF-β Tumor Suppressors to Inhibit Differentiation and Sustain Keratinocyte ProliferationSemantic proximity Read ↗

Comprehensive Analysis of Host Cellular Interactions with Human Papillomavirus E6 Proteins Identifies New E6 Binding Partners and Reflects Viral DiversitySemantic proximity Read ↗

Inhibition of TGF-β and NOTCH Signaling by Cutaneous PapillomavirusesSemantic proximity Read ↗

Human Papillomavirus 16 E6 and E7 Oncoproteins Alter the Abundance of Proteins Associated with DNA Damage Response, Immune Signaling and Epidermal DifferentiationSemantic proximity Read ↗

Post-Transcriptional Gene Regulation by HPV 16E6 and Its Host Protein PartnersSemantic proximity Read ↗

The Human Papillomavirus (HPV) E1 protein regulates the expression of cellular genes involved in immune responseSemantic proximity Read ↗

High-Risk Mucosal Human Papillomavirus 16 (HPV16) E6 Protein and Cutaneous HPV5 and HPV8 E6 Proteins Employ Distinct Strategies To Interfere with Interferon Regulatory Factor 3-Mediated Beta Interferon ExpressionSemantic proximity Read ↗

Genus Beta Human Papillomavirus E6 Proteins Vary in Their Effects on the Transactivation of p53 Target GenesSemantic proximity Read ↗

Modulation of basal cell fate during productive and transforming HPV‐16 infection is mediated by progressive E6‐driven depletion of NotchSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.