Article
The possibility of a valuable resource of circulating DNA for single nucleotide polymorphisms genotyping: the application of a rapid and simple polymerase chain reaction with melting curve analysis for methyltetrahydrofolate reductase polymorphisms.
Laboratory hematology : official publication of the International Society for Laboratory Hematology - 1 Jan 2007
Mori Sayaka, Sugahara Kazuyuki, Uemura Akiko, Yamada Yasuaki, Uzihara Kyouko, Hayashida Hideko, Ideguchi Tsuyoshi, Ishibashi Kiyomi, Nakazato Mio, Maeda Takahiro, Takamura Noboru, Kamihira Shimeru
Abstract excerpt
Circulating DNA from plasma is easily stored and is a valuable resource to access genetic information indispensable to modern hematology. The aim of the present project was to evaluate the integrity of circulating DNA and to investigate whether such DNA is practically tolerable for genotyping single nucleotide polymorphisms (SNP) of methyltetrahydrofolate reductase (MTHFR). We first established a protocol...
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