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Article

Association between CFL1 gene polymorphisms and spina bifida risk in a California population.

BMC medical genetics - 12 Mar 2007

Zhu Huiping, Enaw James O Ebot, Ma Chen, Shaw Gary M, Lammer Edward J, Finnell Richard H

Abstract excerpt

BACKGROUND: CFL1 encodes human non-muscle cofilin (n-cofilin), which is an actin-depolymerizing factor and is essential in cytokinesis, endocytosis, and in the development of all embryonic tissues. Cfl1 knockout mice exhibit failure of neural tube closure at E10.5 and die in utero. We hypothesized that genetic variation within the human CFL1 gene may alter the protein's function and result in defective actin...

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Source

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Identifiers

PMID: 17352815
DOI: 10.1186/1471-2350-8-12
PMCID: PMC1831766

Genes

CFL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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