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Article

Two novel mutations within FREM1 gene in patients with bifid nose.

BMC pediatrics - 14 Dec 2023

Chen Xiaoxue, Yu Baofu, Wang Zi, Li Qingfeng, Dai Chuanchang, Wei Jiao

Abstract excerpt

BACKGROUND: Bifid nose is a rare congenital deformity and the etiology is unknown. The purpose of this study was to report genetic variation in family of patients with bifid nose. METHODS: Twenty-three consecutive patients who were diagnosed with mild bifid nose were operated with z-plasty from 2009 to 2021. Three underage patients (a pair of twins and a girl) from two family lines, who came to our hospital for...

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Identifiers

PMID: 38097983
DOI: 10.1186/s12887-023-04453-9
PMCID: PMC10720098

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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