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Specific functions of TET1 and TET2 in regulating mesenchymal cell lineage determination

2 Jan 2019

Abstract excerpt

BACKGROUND: The 5 hydroxymethylation (5hmC) mark and TET DNA dioxygenases play a pivotal role in embryonic stem cell differentiation and animal development. However, very little is known about TET enzymes in lineage determination of human bone marrow-derived mesenchymal stem/stromal cells (BMSC). We examined the function of all three TET DNA dioxygenases, responsible for DNA hydroxymethylation, in human BMSC cell...

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PMID: 30606231
DOI: 10.1186/s13072-018-0247-4

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