Article
Evidence of genetic heterogeneity in five kindreds with familial hypertrophic cardiomyopathy.
Circulation - 1 Feb 1992
Epstein N D, Fananapazir L, Lin H J, Mulvihill J, White R, Lalouel J M, Lifton R P, Nienhuis A W, Leppert M
Abstract excerpt
BACKGROUND: Recently, two families with hypertrophic cardiomyopathy have been shown to have mutations in the cardiac beta-myosin heavy chain gene (beta-MHC) located on the long arm of chromosome 14. METHODS AND RESULTS: We have performed linkage analysis of five newly ascertained pedigrees with more than 50 chromosomal markers detecting polymorphisms. Our findings confirm the linkage to beta-MHC gene locus on...
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