Article
Evidence of genetic heterogeneity in five kindreds with familial hypertrophic cardiomyopathy.
Circulation - 1 Feb 1992
Epstein N D, Fananapazir L, Lin H J, Mulvihill J, White R, Lalouel J M, Lifton R P, Nienhuis A W, Leppert M
Abstract excerpt
BACKGROUND: Recently, two families with hypertrophic cardiomyopathy have been shown to have mutations in the cardiac beta-myosin heavy chain gene (beta-MHC) located on the long arm of chromosome 14. METHODS AND RESULTS: We have performed linkage analysis of five newly ascertained pedigrees with m...
Topics
- Adolescent
- Adult
- Aged
- Base Sequence
- Cardiomyopathy, Hypertrophic
- Chromosome Mapping
- Chromosomes, Human, Pair 14
- DNA Probes
- Female
- Genes
- Genetic Linkage
- Genetic Markers
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Myosins