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Article

[Genetic heterogeneity of hypertrophic cardiomyopathy in Japanese].

[Hokkaido igaku zasshi] The Hokkaido journal of medical science - 1 Jul 1994

Machida M

Abstract excerpt

Familial hypertrophic cardiomyopathy (FHCM) is thought to be caused by missense mutations in cardiac beta-myosin heavy chain (beta-MHC) gene in 30-40% of affected Caucasian individuals. On the other hand, it has been reported that Japanese FHCM is closely linked to DNA marker PALB on chromosome 18q by linkage analysis. Therefore, in order to elucidate the etiological significance of missense mutations in beta-MHC...

Topics

Asian People
Base Sequence
Cardiomyopathy, Hypertrophic
Chromosome Mapping
Chromosomes, Human, Pair 18
DNA
Humans
Japan
Molecular Sequence Data
Mutation
Myosins
Polymerase Chain Reaction

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PMID: 7959583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7959583-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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