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Article

Glibenclamide binding to sulphonylurea receptor subtypes: dependence on adenine nucleotides.

British journal of pharmacology - 1 Aug 2002

Hambrock Annette, Löffler-Walz Cornelia, Quast Ulrich

Abstract excerpt

1: ATP-sensitive K(+) channels are composed of pore-forming subunits Kir6.2 and of sulphonylurea receptors (SURs); the latter are the target of the hypoglycaemic sulphonylureas like glibenclamide. Here, we report on the negative allosteric modulation by MgATP and MgADP of glibenclamide binding to SUR1 and to SUR2 mutants with high glibenclamide affinity, SUR2A(Y1206S) and SUR2B(Y1206S). 2: ATP, in the presence of...

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Identifiers

PMID: 12145099
DOI: 10.1038/sj.bjp.0704801
PMCID: PMC1573429

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Glibenclamide binding to sulphonylurea receptor subtypes: dependence on adenine nucleotides.PMID 12145099Read ↗

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