Article
Both the dimerization and immunochemical properties of E-cadherin EC1 domain depend on Trp(156) residue.
Archives of biochemistry and biophysics - 1 Apr 2002
Laur Oscar Y, Klingelhöfer Jörg, Troyanovsky Regina B, Troyanovsky Sergey M
Abstract excerpt
Using site-directed mutagenesis, we show in this paper that the adhesive interface detected in cadherin crystals is unlikely to mediate adhesive interaction between myc- and flag-tagged E-cadherin molecules in human A-431 cells. We also found that a critical residue within this interface, His(233), is part of the epitope for mAb SHE78-7. This epitope was accessible to the antibody in the adhesive E-cadherin...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.