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Article

Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1.

BMC medical genetics - 8 Mar 2007

Sacco Roberto, Papaleo Veruska, Hager Jorg, Rousseau Francis, Moessner Rainald, Militerni Roberto, Bravaccio Carmela, Trillo Simona, Schneider Cindy, Melmed Raun, Elia Maurizio, Curatolo Paolo, Manzi Barbara, Pascucci Tiziana, Puglisi-Allegra Stefano, Reichelt Karl-Ludvig, Persico Antonio M

Abstract excerpt

BACKGROUND: The TPH2 gene encodes the enzyme responsible for serotonin (5-HT) synthesis in the Central Nervous System (CNS). Stereotypic and repetitive behaviors are influenced by 5-HT, and initial studies report an association of TPH2 alleles with childhood-onset obsessive-compulsive disorder (OCD) and with autism. GLO1 encodes glyoxalase I, the enzyme which detoxifies alpha-oxoaldehydes such as methylglyoxal in...

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Source

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Identifiers

PMID: 17346350
DOI: 10.1186/1471-2350-8-11
PMCID: PMC1851007

Genes

GLO1
TPH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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