Article
Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification.
Journal of lipid research - 1 Jun 2007
Westerterp Marit, Berbée Jimmy F P, Delsing Dianne J M, Jong Miek C, Gijbels Marion J J, Dahlmans Vivian E H, Offerman Erik H, Romijn Johannes A, Havekes Louis M, Rensen Patrick C N
Abstract excerpt
Mice that overexpress human apolipoprotein C-I (apoC-I) homozygously (APOC1(+/+) mice) are protected against obesity and show cutaneous abnormalities. Although these effects can result from our previous observation that apoC-I inhibits FFA generation by LPL, we have also found that apoC-I impairs the uptake of a FFA analog in adipose tissue. In this study, we tested the hypothesis that apoC-I interferes with...
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