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Article

Alpha-synuclein overexpression reduces gap junctional intercellular communication in dopaminergic neuroblastoma cells.

Neuroscience letters - 18 Apr 2007

Sung Jee Young, Lee Hyun Jung, Jeong Eun Il, Oh Yohan, Park Joongkyu, Kang Kyung-Sun, Chung Kwang Chul

Abstract excerpt

Alpha-synuclein has been implicated in the pathology of certain neurodegenerative diseases, including Parkinson disease (PD) and dementia with Lewy bodies (LBs). Overexpression of human alpha-synuclein in neuronal cells reduces cell viability, but the precise cellular and molecular mechanisms remain poorly understood. Gap junctional intercellular communication (GJIC) is thought to be essential for maintaining...

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PMID: 17337120
DOI: 10.1016/j.neulet.2007.02.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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