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Article

MSH2 c.1452-1455delAATG is a founder mutation and an important cause of hereditary nonpolyposis colorectal cancer in the southern Chinese population.

American journal of human genetics - 1 May 2004

Chan Tsun Leung, Chan Yee Wai, Ho Judy W C, Chan Celine, Chan Annie S Y, Chan Emily, Lam Polly W Y, Tse Chun Wah, Lee Kam Cheong, Lau Chi Waii, Gwi Elaine, Leung Suet Yi, Yuen Siu Tsan

Abstract excerpt

Hereditary nonpolyposis colorectal cancer (HNPCC) accounts for approximately 2% of all colorectal cancer (CRC) cases and is the most common hereditary CRC syndrome. We have previously reported a high incidence of microsatellite instability (MSI) and germline mismatch repair (MMR) gene mutations in young Hong Kong Chinese with CRC. Ongoing studies at the Hereditary Gastrointestinal Cancer Registry in Hong Kong...

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Share to Colorectal Neoplasms, Hereditary Nonpolyposis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15042510
DOI: 10.1086/383591
PMCID: PMC1181966

Genes

MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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