Article
Collagen type 1 (COL1A1) Sp1 binding site polymorphism is associated with osteoporotic fractures but not with bone density in post-menopausal women from the Canary Islands: a preliminary study.
Aging clinical and experimental research - 1 Feb 2007
Navarro Mary C, Sosa Manuel, del Pino-Montes Javier, Torres Armando, Salido Eduardo, Saavedra Pedro, Corral-Gudino Luis, Montilla Carlos A
Abstract excerpt
BACKGROUND AND AIMS: An association between the polymorphism for transcription factor Sp1 in the gene COL1A1 and low bone density (BMD) and osteoporotic fractures has been described but not confirmed for all races and ages. The aim of this preliminary work was to ascertain whether this association is present in women from the Canary Islands. METHODS: Polymerase chain reaction RFLP was used to determine COL1A1...
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