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Article

Differential constitutive activation of the epidermal growth factor receptor in non-small cell lung cancer cells bearing EGFR gene mutation and amplification.

Cancer research - 1 Mar 2007

Okabe Takafumi, Okamoto Isamu, Tamura Kenji, Terashima Masaaki, Yoshida Takeshi, Satoh Taroh, Takada Minoru, Fukuoka Masahiro, Nakagawa Kazuhiko

Abstract excerpt

The identification of somatic mutations in the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) in patients with non-small cell lung cancer (NSCLC) and the association of such mutations with the clinical response to EGFR tyrosine kinase inhibitors (TKI), such as gefitinib and erlotinib, have had a substantial effect on the treatment of this disease. EGFR gene amplification has also been...

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PMID: 17332333
DOI: 10.1158/0008-5472.CAN-06-3339

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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