Article
Differential constitutive activation of the epidermal growth factor receptor in non-small cell lung cancer cells bearing EGFR gene mutation and amplification.
Cancer research - 1 Mar 2007
Okabe Takafumi, Okamoto Isamu, Tamura Kenji, Terashima Masaaki, Yoshida Takeshi, Satoh Taroh, Takada Minoru, Fukuoka Masahiro, Nakagawa Kazuhiko
Abstract excerpt
The identification of somatic mutations in the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) in patients with non-small cell lung cancer (NSCLC) and the association of such mutations with the clinical response to EGFR tyrosine kinase inhibitors (TKI), such as gefitinib and...
Topics
- Base Sequence
- Carcinoma, Non-Small-Cell Lung
- Cell Proliferation
- DNA Mutational Analysis
- ErbB Receptors
- Gefitinib
- Gene Amplification
- Gene Expression Regulation, Neoplastic
- Humans
- Lung Neoplasms
- Molecular Sequence Data
- Mutation
- Phosphorylation