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Article

Reciprocal and complementary role of MET amplification and EGFR T790M mutation in acquired resistance to kinase inhibitors in lung cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2010

Suda Kenichi, Murakami Isao, Katayama Tatsuya, Tomizawa Kenji, Osada Hirotaka, Sekido Yoshitaka, Maehara Yoshihiko, Yatabe Yasushi, Mitsudomi Tetsuya

Abstract excerpt

PURPOSE: In epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy for lung cancer patients, acquired resistance develops almost inevitably and this limits the improvement in patient outcomes. EGFR T790M mutation and MET amplification are the two main mechanisms underlying this resistance, but the relationship between these two mechanisms is unclear. In this study, we explored their...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21062933
DOI: 10.1158/1078-0432.CCR-10-1371

Genes

MET
EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Reciprocal and complementary role of MET amplification and EGFR T790M mutation in acquired resistance to kinase inhibitors in lung cancer.PMID 21062933Read ↗

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