Article
Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations.
Blood - 15 Jun 2007
Matsuda Kazuyuki, Shimada Akira, Yoshida Nao, Ogawa Atsushi, Watanabe Akihiro, Yajima Shuhei, Iizuka Susumu, Koike Kazutoshi, Yanai Fumio, Kawasaki Keiichiro, Yanagimachi Masakatsu, Kikuchi Akira, Ohtsuka Yoshitoshi, Hidaka Eiko, Yamauchi Kazuyoshi, Tanaka Miyuki, Yanagisawa Ryu, Nakazawa Yozo, Shiohara Masaaki, Manabe Atsushi, Kojima Seiji, Koike Kenichi
Abstract excerpt
Of 11 children with juvenile myelomonocytic leukemia (JMML) carrying RAS mutations (8 with NRAS mutations, 3 with KRAS2 mutations), 5 had a profound elevation in either or both the white blood cells and spleen size at diagnosis. Three patients had no or modest hepatosplenomegaly and mild leukocyt...
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