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Article

Distinct pattern of allelic loss and inactivation of cadherin 1 and 5 genes in mammary carcinomas arising in p53(+/-) mice.

Journal of radiation research - 1 Mar 2007

Umesako Seiichi, Iiga Sayoko, Takahashi Masahiro, Imura Kae, Mori Nobuko, Hong Doo-Pyo, Song Chang-Woo, Niwa Otsura, Okumoto Masaaki

Abstract excerpt

p53 is one of the most frequently mutated genes in mammary carcinomas (MCs). To detect tumor suppressor genes cooperating with a hetero-deficient p53 gene in mammary carcinogenesis, we first examined allelotypes in MCs from (BALB/cHeA x MSM/Ms) F(1)- p53(+/-) and (BALB/cHeA x 129/SvEv) F(1)- p53(+/-) female mice, and then surveyed down-regulated genes in the allelic loss regions. Genome-wide screening at 42 loci...

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Share to Antigens, CD
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

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Share to Mammary Neoplasms, Animal

Share to Mice, Inbred BALB C

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Source

Identifiers

PMID: 17327688
DOI: 10.1269/jrr.06064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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