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Article

Effects of TGF-β2, BMP-4, and Gremlin in the Trabecular Meshwork: Implications for Glaucoma

26 Feb 2007

Abstract excerpt

PURPOSE: The primary causative factor of primary open-angle glaucoma (POAG) is elevated intraocular pressure (IOP) due to increased aqueous humor (AH) outflow resistance, which is associated with morphologic and biochemical changes in the trabecular meshwork (TM). Patients with glaucoma have elevated levels of transforming growth factor (TGF)-beta2 in their AH, and TGF-beta has been shown to increase TM...

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PMID: 17325163
DOI: 10.1167/iovs.06-0296

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Effects of TGF-β2, BMP-4, and Gremlin in the Trabecular Meshwork: Implications for GlaucomaPMID 17325163Read ↗

The Role of TGF-β2 and Bone Morphogenetic Proteins in the Trabecular Meshwork and GlaucomaSemantic proximity Read ↗

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The TGFβ Induced MicroRNAome of the Trabecular MeshworkSemantic proximity Read ↗

Fibrosis-Related Gene and Protein Expression in Normal and Glaucomatous Trabecular Meshwork CellsSemantic proximity Read ↗

Regulation of BMP genes, EMC production and deposition through TGFβ/Smad Signaling in Human Trabecular Meshwork for progression of glaucoma diseaseSemantic proximity Read ↗

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Suppression of TGF-β1 signaling by Matrigel via FAK signaling in cultured human trabecular meshwork cells.Semantic proximity Read ↗

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