Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of TGFβ/Smad Signaling in Gremlin Induction of Human Trabecular Meshwork Extracellular Matrix Proteins

4 Jun 2011

Abstract excerpt

PURPOSE: The bone morphogenic protein (BMP) antagonist gremlin is elevated in glaucomatous trabecular meshwork (TM) cells and tissues and elevates intraocular pressure (IOP). Gremlin also blocks BMP4 inhibition of transforming growth factor (TGF)-β2 induction of TM extracellular matrix (ECM) proteins. The purpose of this study was to determine whether Gremlin regulates ECM proteins in cultured human TM cells....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glaucoma and retinal disorders
Share to Proteoglycans and glycosaminoglycans research
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21642622
DOI: 10.1167/iovs.11-7587

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of TGFβ/Smad Signaling in Gremlin Induction of Human Trabecular Meshwork Extracellular Matrix ProteinsPMID 21642622Read ↗

Effects of TGF-β2, BMP-4, and Gremlin in the Trabecular Meshwork: Implications for GlaucomaSemantic proximity Read ↗

Gremlin utilizes canonical and non-canonical TGFβ signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cellsSemantic proximity Read ↗

The Role of TGF-β2 and Bone Morphogenetic Proteins in the Trabecular Meshwork and GlaucomaSemantic proximity Read ↗

Fibrosis-Related Gene and Protein Expression in Normal and Glaucomatous Trabecular Meshwork CellsSemantic proximity Read ↗

Genome-wide transcriptome profiling of human trabecular meshwork cells treated with TGF-β2Semantic proximity Read ↗

Genome-Wide Transcriptome Profiling of Human Trabecular Meshwork Cells Treated with TGF-β2.Semantic proximity Read ↗

Suppression of TGF-β1 signaling by Matrigel via FAK signaling in cultured human trabecular meshwork cells.Semantic proximity Read ↗

The TGFβ Induced MicroRNAome of the Trabecular MeshworkSemantic proximity Read ↗

Wnt Activation After Inhibition Restores Trabecular Meshwork Cells Toward a Normal Phenotype.Semantic proximity Read ↗

Macrophage Migration Inhibitory Factor (MIF)-CD74 Signaling Pathway Mediates Trabecular Meshwork Dysfunction in GlaucomaSemantic proximity Read ↗

Regulation of BMP genes, EMC production and deposition through TGFβ/Smad Signaling in Human Trabecular Meshwork for progression of glaucoma diseaseSemantic proximity Read ↗

Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshwork.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.