Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell RNA-Seq reveals transcriptional heterogeneity and immune subtypes associated with disease activity in human myasthenia gravis

14 Sept 2021

Abstract excerpt

Abstract Myasthenia gravis (MG) is a rare autoimmune disease. Although the impact of immune cell disorder in MG has been extensively studied, little is known about the transcriptomes of individual cells. Here, we assessed the transcriptional profiles of 39,243 cells by single-cell sequencing and identified 13 major cell clusters, along with 39 subgroups of cells derived from patients with new-onset myasthenia...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Myasthenia Gravis and Thymoma
Share to Single-cell and spatial transcriptomics
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34521820
DOI: 10.1038/s41421-021-00314-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell RNA-Seq reveals transcriptional heterogeneity and immune subtypes associated with disease activity in human myasthenia gravisPMID 34521820Read ↗

Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signatureSemantic proximity Read ↗

Peripheral immune landscape for hypercytokinemia in myasthenic crisis utilizing single-cell transcriptomicsSemantic proximity Read ↗

CFD+CD14+ monocytes: potential pathogenic subset in myasthenia gravis uncovered by multi-omics integration and machine learning analysis.Semantic proximity Read ↗

Differential Transcription Profiling in Bone Marrow Mononuclear Cells Between Myasthenia Gravis Patients With or Without ThymomaSemantic proximity Read ↗

Single-Cell RNA-Sequencing Integration Analysis Revealed Immune Cell Heterogeneity in Five Human Autoimmune DiseasesSemantic proximity Read ↗

Rheumatoid arthritis, systemic lupus erythematosus and primary Sjögren's syndrome shared megakaryocyte expansion in peripheral bloodSemantic proximity Read ↗

Methylome and transcriptome profiling in Myasthenia Gravis monozygotic twins.Semantic proximity Read ↗

A novel infection- and inflammation-associated molecular signature in peripheral blood of myasthenia gravis patientsSemantic proximity Read ↗

Single-cell transcriptome analysis and protein profiling reveal broad immune system activation in IgG4-related diseaseSemantic proximity Read ↗

Defining Inflammatory Cell States in Rheumatoid Arthritis Joint Synovial Tissues by Integrating Single-cell Transcriptomics and Mass CytometrySemantic proximity Read ↗

Single-cell RNA sequencing reveals cell type-specific immune regulation associated with human neuromyelitis optica spectrum disorderSemantic proximity Read ↗

Elucidating genetic backgrounds of myasthenia gravis in Japanese by genome-wide association studies and multi-omics analyses of thymoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.