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Article

Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis.

Nature - 29 Mar 2007

Veiga-Fernandes Henrique, Coles Mark C, Foster Katie E, Patel Amisha, Williams Adam, Natarajan Dipa, Barlow Amanda, Pachnis Vassilis, Kioussis Dimitris

Abstract excerpt

Normal organogenesis requires co-ordinate development and interaction of multiple cell types, and is seemingly governed by tissue specific factors. Lymphoid organogenesis during embryonic life is dependent on molecules the temporal expression of which is tightly regulated. During this process, ha...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17322904
DOI: 10.1038/nature05597

Genes

RET
ARTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17322904-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis.PMID 17322904Read ↗

Ret receptor tyrosine kinase sustains proliferation and tissue maturation in intestinal epitheliaSemantic proximity Read ↗

Multipotential progenitors of the mammalian enteric nervous system capable of colonising aganglionic bowel in organ culture.Semantic proximity Read ↗

Expression pattern of <i>Drosophila ret</i> suggests a common ancestral origin between the metamorphosis precursors in insect endoderm and the vertebrate enteric neuronsSemantic proximity Read ↗

<i>In Toto</i> imaging of early Enteric Nervous System Development reveals that gut colonization is tied to proliferation downstream of RetSemantic proximity Read ↗

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret.Semantic proximity Read ↗

Ret deficiency decreases neural crest progenitor proliferation and restricts fate potential during enteric nervous system developmentSemantic proximity Read ↗

Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in miceSemantic proximity Read ↗

The Drosophila Ret gene functions in the stomatogastric nervous system with the Maverick TGFβ ligand and the Gfrl co-receptor.Semantic proximity Read ↗

RET Signaling Persists in the Adult Intestine and Stimulates Motility by Limiting PYY Release from Enteroendocrine CellsSemantic proximity Read ↗

Requirement of signalling by receptor tyrosine kinase RET for the directed migration of enteric nervous system progenitor cells during mammalian embryogenesis.Semantic proximity Read ↗

The RET receptor: function in development and dysfunction in congenital malformation.Semantic proximity Read ↗

Retinoic Acid Upregulates Ret and Induces Chain Migration and Population Expansion in Vagal Neural Crest Cells to Colonise the Embryonic GutSemantic proximity Read ↗

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