Expression pattern of <i>Drosophila ret</i> suggests a common ancestral origin between the metamorphosis precursors in insect endoderm and the vertebrate enteric neurons

Abstract excerpt

The RET gene, encoding a receptor tyrosine kinase, is unusual among human protooncogenes in that its mutant alleles are implicated in a developmental defect involving enteric neurons as well as in tumorigenesis. The cells affected in both types of disorders are derived from the neural crest. Targeted disruption of mouse ret has revealed an additional role in kidney development. Here we report the analysis of a...

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