Article
Model-based linkage analyses confirm chromosome 19q13.3 as a susceptibility locus for intracranial aneurysm.
Stroke - 1 Apr 2007
Mineharu Youhei, Inoue Kayoko, Inoue Sumiko, Yamada Shigeki, Nozaki Kazuhiko, Hashimoto Nobuo, Koizumi Akio
Abstract excerpt
BACKGROUND AND PURPOSE: In previous studies of familial intracranial aneurysm (IA), parametric linkage analyses have been undertaken for five unrelated families, four providing maximum logarithm of odds (LOD) scores with dominant models and one with a recessive model. Each family was linked to a distinct locus, indicating locus heterogeneity. This study aimed to examine whether Japanese IA families consistent...
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