Article
Genome scan for familial abdominal aortic aneurysm using sex and family history as covariates suggests genetic heterogeneity and identifies linkage to chromosome 19q13.
Circulation - 4 May 2004
Shibamura Hidenori, Olson Jane M, van Vlijmen-Van Keulen Clarissa, Buxbaum Sarah G, Dudek Doreen M, Tromp Gerard, Ogata Toru, Skunca Magdalena, Sakalihasan Natzi, Pals Gerard, Limet Raymond, MacKean Gerald L, Defawe Olivier, Verloes Alain, Arthur Claudette, Lossing Alan G, Burnett Marjorie, Sueda Taijiro, Kuivaniemi Helena
Abstract excerpt
BACKGROUND: Abdominal aortic aneurysm (AAA) is a relatively common disease, with 1% to 2% of the population harboring aneurysms. Genetic risk factors are likely to contribute to the development of AAAs, although no such risk factors have been identified. METHODS AND RESULTS: We performed a whole-genome scan of AAA using affected-relative-pair (ARP) linkage analysis that includes covariates to allow for genetic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.