Article
Genome-wide linkage in three Dutch families maps a locus for abdominal aortic aneurysms to chromosome 19q13.3.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery - 1 Jul 2005
Van Vlijmen-Van Keulen C J, Rauwerda J A, Pals G
Abstract excerpt
OBJECTIVES: Elucidation of the genetic background of familial abdominal aortic aneurysm (AAA) suggests a genetic etiology. METHODS AND RESULTS: We carried out a genome-wide scan in three Dutch families with four or five affected siblings. Suggestive loci were further studied by subsequent fine mapping of the locus performed in 101 affected sib-pairs. The genome-wide scan was performed with 400 DNA markers and...
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