Article
Protein-bound crotonaldehyde accumulates in the spinal cord of superoxide dismutase-1 mutation-associated familial amyotrophic lateral sclerosis and its transgenic mouse model.
Neuropathology : official journal of the Japanese Society of Neuropathology - 1 Feb 2007
Shibata Noriyuki, Kawaguchi Motoko, Uchida Koji, Kakita Akiyoshi, Takahashi Hitoshi, Nakano Ryoichi, Fujimura Harutoshi, Sakoda Saburo, Ihara Yuetsu, Nobukuni Keigo, Takehisa Yasushi, Kuroda Shigetoshi, Kokubo Yasumasa, Kuzuhara Shigeki, Honma Taku, Mochizuki Yoko, Mizutani Tomohiko, Yamada Satoshi, Toi Sono, Sasaki Shoichi, Iwata Makoto, Hirano Asao, Yamamoto Tomoko, Kato Yoichiro, Sawada Tatsuo, Kobayashi Makio
Abstract excerpt
Growing evidence documents oxidative stress involvement in ALS. We previously demonstrated accumulation of a protein-bound form of the highly toxic lipid peroxidation product crotonaldehyde (CRA) in the spinal cord of sporadic ALS patients. In the present study, to the determine the role for CRA in the disease processes of superoxide dismutase-1 (SOD1) mutation-associated familial ALS (FALS), we performed...
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