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Article

Redox susceptibility of SOD1 mutants is associated with the differential response to CCS over-expression in vivo.

Neurobiology of disease - 1 Apr 2009

Son Marjatta, Fu Qiao, Puttaparthi Krishna, Matthews Christina M, Elliott Jeffrey L

Abstract excerpt

Over-expression of CCS in G93A SOD1 mice accelerates neurological disease and enhances mitochondrial pathology. We studied the effect of CCS over-expression in transgenic mice expressing G37R, G86R or L126Z SOD1 mutations in order to understand factors which influence mitochondrial dysfunction. Over-expression of CCS markedly decreased survival and produced mitochondrial vacuolation in G37R SOD1 mice but not in...

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Identifiers

PMID: 19320055
DOI: 10.1016/j.nbd.2009.01.005
PMCID: PMC2835407

Genes

SOD1
CCS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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