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Article

Selective formation of certain advanced glycation end products in spinal cord astrocytes of humans and mice with superoxide dismutase-1 mutation.

Acta neuropathologica - 1 Aug 2002

Shibata Noriyuki, Hirano Asao, Hedley-Whyte E Tessa, Dal Canto Mauro C, Nagai Ryoji, Uchida Koji, Horiuchi Seikoh, Kawaguchi Motoko, Yamamoto Tomoko, Kobayashi Makio

Abstract excerpt

Recent studies have documented carbonyl stress involvement in the pathogenesis of sporadic amyotrophic lateral sclerosis (ALS). The aim of the present study was to assess a role for carbonyl stress in motor neuron degeneration associated with superoxide dismutase-1 (SOD1) mutant familial ALS and its transgenic mouse model, using an immunohistochemical investigation of advanced glycation end products (AGEs) and...

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Source

Identifiers

PMID: 12111360
DOI: 10.1007/s00401-002-0537-5

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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