Article
DNMT3b 39179GT polymorphism and the risk of adenocarcinoma of the colon in Koreans.
Biochemical genetics - 1 Apr 2007
Hong Young-Seoub, Lee Hye-Jung, You Chang-Hun, Roh Mee-Sook, Kwak Jong-Young, Lee Myeong-Jin, Kim Joon-Youn
Abstract excerpt
DNA-methyltransferase-3B (DNMT3b) plays an important role in the generation of aberrant methylation in carcinogenesis. DNMT3b SNP has been associated with susceptibility to lung, head, neck, and breast cancer, but its association with the development of colon cancer has not been reported. We investigated the relationship between the 39179GT polymorphism in the DNMT3b gene, which is involved in de novo methylation...
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