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Article

Distinct Roles for Rac1 in Sertoli Cell Function during Testicular Development and Spermatogenesis

1 Apr 2020

Abstract excerpt

Sertoli cells are supporting cells of the testicular seminiferous tubules, which provide a nurturing environment for spermatogenesis. Adult Sertoli cells are polarized so that they can simultaneously support earlier-stage spermatogenic cells (e.g., spermatogonia) basally and later-stage cells (e.g., spermatids) apically. To test the consequences of disrupting cell polarity in Sertoli cells, we perform a...

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PMID: 32294451
DOI: 10.1016/j.celrep.2020.03.077

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