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Article

ARHGEF15 in Sertoli cells contributes to germ cell development and testicular immune privilege

24 Aug 2022

Abstract excerpt

Sertoli cells (SCs), the only somatic cells in the seminiferous tubules, facilitate the maintenance of testicular immune privilege through the formation of the blood-testis barrier (BTB) and the expression of immunoregulatory factors. Rho guanosine exchange factor 15 (ARHGEF15) is a member of the guanosine exchange factors, which are involved in cell migration, cell polarity, and cell cycle progression via...

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PMID: 36001358
DOI: 10.1093/biolre/ioac166

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