Article
Characterization of the Basal promoter element of human organic cation transporter 2 gene.
The Journal of pharmacology and experimental therapeutics - 1 May 2007
Asaka Jun-ichi, Terada Tomohiro, Ogasawara Ken, Katsura Toshiya, Inui Ken-ichi
Abstract excerpt
Human organic cation transporter 2 (hOCT2; SLC22A2) is abundantly expressed in the kidney, and it plays important roles in the renal tubular secretion of cationic drugs. Although the transport characteristics of hOCT2 have been studied extensively, there is no information available for the transcriptional regulation of hOCT2. The present study was undertaken to identify the cis-element and trans-factor for basal...
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