Article
Characterization of human OATP2B1 (SLCO2B1) gene promoter regulation.
Pharmaceutical research - 1 Mar 2006
Maeda Tomoji, Hirayama Masamichi, Higashi Ryunosuke, Sato Masanobu, Tamai Ikumi
Abstract excerpt
PURPOSE: We investigated transcriptional regulation of organic anion transporter OATP2B1 (SLCO2B1) that is expressed in multiple tissues such as liver, small intestine, and others and compared it with that of liver-specific OATPs. METHODS: The promoter activity was examined by luciferase assay. Specific bindings of transcription factors to the promoter region were examined by gel mobility shift assay using native...
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