Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrative genomics analysis of chromosome 5p gain in cervical cancer reveals target over-expressed genes, including Drosha.

Molecular cancer - 17 Jun 2008

Scotto Luigi, Narayan Gopeshwar, Nandula Subhadra V, Subramaniyam Shivakumar, Kaufmann Andreas M, Wright Jason D, Pothuri Bhavana, Mansukhani Mahesh, Schneider Achim, Arias-Pulido Hugo, Murty Vundavalli V

Abstract excerpt

BACKGROUND: Copy number gains and amplifications are characteristic feature of cervical cancer (CC) genomes for which the underlying mechanisms are unclear. These changes may possess oncogenic properties by deregulating tumor-related genes. Gain of short arm of chromosome 5 (5p) is the most frequent karyotypic change in CC. METHODS: To examine the role of 5p gain, we performed a combination of single nucleotide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 5
Share to Colombia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Amplification

Share to New York

Share to Precancerous Conditions

Share to Ribonuclease III

Share to Uterine Cervical Dysplasia

Share to Uterine Cervical Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 18559093
DOI: 10.1186/1476-4598-7-58
PMCID: PMC2440550

Genes

BASP1
BRD9
NDUFS6
NNT
OSMR
PAIP1
RAD1
SDHA
SKP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrative genomics analysis of chromosome 5p gain in cervical cancer reveals target over-expressed genes, including Drosha.PMID 18559093Read ↗

Integrative Genomic Approaches in Cervical Cancer: Implications for Molecular PathogenesisSemantic proximity Read ↗

Functional evidence that Drosha overexpression in cervical squamous cell carcinoma affects cell phenotype and microRNA profiles.Semantic proximity Read ↗

Amplified genes may be overexpressed, unchanged, or downregulated in cervical cancer cell lines.Semantic proximity Read ↗

Identification of copy number gain and overexpressed genes on chromosome arm 20q by an integrative genomic approach in cervical cancer: potential role in progression.Semantic proximity Read ↗

Identification of Potential Driver Genes Based on Multi-Genomic Data in Cervical CancerSemantic proximity Read ↗

Identification of Significant Gene Signatures and Prognostic Biomarkers for Patients With Cervical Cancer by Integrated Bioinformatic MethodsSemantic proximity Read ↗

Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex genetic alterations in cervical cancer.Semantic proximity Read ↗

The relationships of genetic polymorphisms of the long noncoding RNA growth arrest-specific transcript 5 with uterine cervical cancer.Semantic proximity Read ↗

Long Non-Coding RNA LINC00511 Accelerates Proliferation and Invasion in Cervical Cancer Through Targeting miR-324-5p/DRAM1 AxisSemantic proximity Read ↗

Integrative genomic and network analysis identified novel genes associated with the development of advanced cervical squamous cell carcinoma.Semantic proximity Read ↗

Chromosomal amplifications, 3q gain and deletions of 2q33-q37 are the frequent genetic changes in cervical carcinomaSemantic proximity Read ↗

Genome-wide copy number analyses identified novel cancer genes in hepatocellular carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.