Lengths of truncated forms of apolipoprotein B (apoB) determine their intestinal production.

doi:10.1016/0006-291x(92)92313-m

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Article

Lengths of truncated forms of apolipoprotein B (apoB) determine their intestinal production.

Biochemical and biophysical research communications - 15 Dec 1992

Krul E S, Tang J, Kettler T S, Clouse R E, Schonfeld G

Abstract excerpt

Most truncations of apoB associated with hypobetalipoproteinemia (HBL) result from frame shift mutations of the apoB gene that give rise to premature stop codons and truncations of C-terminal sequences. The "natural" truncation, apoB-48, arises from a stop codon by cotranscriptional editing of intestinal apoB-100 mRNA. We hypothesized that mutant apoB mRNA would be normally edited and that only those apoB...

Topics

Apolipoproteins B
Cholesterol
Cholesterol, LDL
Codon
Duodenum
Female
Frameshift Mutation
Heterozygote
Humans
Hypobetalipoproteinemias
Intestinal Mucosa

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Methionine

Phenotype

RNA Processing, Post-Transcriptional

RNA, Messenger

Reference Values

Sulfur Radioisotopes

Source

Open in PubMed

Identifiers

PMID: 1472017
DOI: 10.1016/0006-291x(92)92313-m

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1472017-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Lengths of truncated forms of apolipoprotein B (apoB) determine their intestinal production.PMID 1472017Read ↗

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