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Article

An enzymatic mutant of Shiga-like toxin II variant is a vaccine candidate for edema disease of swine.

Infection and immunity - 1 Feb 1992

Gordon V M, Whipp S C, Moon H W, O'Brien A D, Samuel J E

Abstract excerpt

Edema disease (ED) of weanling pigs is caused by an infection with Escherichia coli that produces Shiga-like toxin II variant (SLT-IIv). Pathology identical to that caused by ED can be duplicated in pigs that are injected with less than 10 ng of purified SLT-IIv per kg of body weight. Therefore, SLT-IIv was mutated to create an immunoreactive form of the toxin that was significantly reduced in enzymatic activity....

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Source

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Identifiers

PMID: 1730480
DOI: 10.1128/iai.60.2.485-490.1992
PMCID: PMC257653

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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