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Article

Rab 5 Is Required for the Cellular Entry of Dengue and West Nile Viruses

15 Feb 2007

Abstract excerpt

The mechanisms of cellular entry of dengue and West Nile viruses are not well characterized. We show that both these viruses enter HeLa cells by clathrin-dependent endocytosis and require vacuolar acidic pH. Inhibition of the GTPase Rab 5 or 7, which regulates transport to early or late endosomes, respectively, demonstrated that Rab 5 was essential for survival of both dengue and West Nile virus. These data...

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PMID: 17301152
DOI: 10.1128/jvi.02210-06

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