Complement C4 null alleles as a marker of gold or D-penicillamine toxicity in the treatment of rheumatoid arthritis.

doi:10.1093/rheumatology/31.1.53

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Article

Complement C4 null alleles as a marker of gold or D-penicillamine toxicity in the treatment of rheumatoid arthritis.

British journal of rheumatology - 1 Jan 1992

Clarkson R W, Sanders P A, Grennan D M

Abstract excerpt

C4 null alleles and HLA-DR antigens were defined in 48 rheumatoid arthritis (RA) subjects who had developed renal or heamatological side effects to gold or penicillamine, as compared to 33 RA subjects who had received the drugs for similar time periods without developing side effects. A C4A null allele was found in 56% of subjects with and 31% of those without side effects (P = 0.027, relative risk 2.8). A...

Topics

Alleles
Amino Acid Sequence
Arthritis, Rheumatoid
Complement C4
Gene Frequency
Genetic Markers
Gold
HLA-DR3 Antigen
Humans
Molecular Sequence Data
Penicillamine

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