Article
Recruitment of Dbl by ezrin and dystroglycan drives membrane proximal Cdc42 activation and filopodia formation.
Cell cycle (Georgetown, Tex.) - 1 Feb 2007
Batchelor Clare L, Higginson Jen R, Chen Yun-Ju, Vanni Cristina, Eva Alessandra, Winder Steve J
Abstract excerpt
Dystroglycan is an essential laminin binding cell adhesion molecule, which is also an adaptor for several SH2 domain-containing signaling molecules and as a scaffold for the ERK-MAP kinase cascade. Loss of dystroglycan function is implicated in muscular dystrophies and the aetiology of epithelial cancers. We have previously demonstrated a role for dystroglycan and ezrin in the formation of filopodia structures....
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