Article
Somatic mutations of the beta-TrCP gene in gastric cancer.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Feb 2007
Kim Chang Jae, Song Jae Hwi, Cho Yong Gu, Kim Young Sill, Kim Su Young, Nam Suk Woo, Yoo Nam Jin, Lee Jung Young, Park Won Sang
Abstract excerpt
Beta-TrCP is a component of the ubiquitin ligase complex targeting beta-catenin for proteasomal degradation, and is a negative regulator of Wnt/beta-catenin signaling. To determine whether genetic alterations of the beta-TrCP gene are involved in the development or progression of gastric cancer, we analyzed its somatic mutations in 95 gastric cancers by single-strand conformational polymorphism and sequencing. We...
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